反应详情

温度

44 °C

To a solution of Intermediate 1D (0.94 g, 3.24 mmol) in DCM (30 mL) was added thionyl chloride (0.95 mL, 12.96 mmol). The resulting mixture was stirred at 44° C. overnight and allowed to cool to ambient temperature. The mixture was concentrated under reduced pressure, azeotroped with acetonitrile and dried under vacuum overnight to give Intermediate 1E in quantitative yield as a white solid which was used in the next step without further purification.

1. temperatureto cool to ambient temperature
2. concentrationThe mixture was concentrated under reduced pressure
3. customazeotroped with acetonitrile
4. customdried under vacuum overnight