HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Amino-N,3,3-trimethylbutanamide → (S)-tert-butyl 3-benzoyl-1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Amino-N,3,3-trimethylbutanamide | HCID 445856 | — |
| Reactant | Imidazo[1,5-a]pyrazine-1,7(8h)-dicarboxylic acid,3-benzoyl-5,6-dihydro-,7-(1,1-dimethylethyl)ester | HCID 57635676 | — |
| Product | (S)-tert-butyl 3-benzoyl-1-(3,3-dimethyl-1-(methylamino)-1-oxobutan-2-ylcarbamoyl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxylate | HCID 57635475 | — |
Reaction Steps
Intermediate 25B was synthesized in the same manner as described above for compound 22A in Example 22 except that Intermediate 25A was used in place of 3B and L-tert-Leucine methylamide was used instead of (S)-methyl 2-amino-3,3-dimethylbutanoate. LCMS (+ESI) m/z 498.3 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859538B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-46c071aee930479eb514f372e32095d7 |
| Source note | uspto-grants-2014_10 |