反应详情

A mixture of 8-(1-benzyl-1H-pyrazol-4-yl)-2-chloro-1-propyl-1,7-dihydro-purin-6-one (0.035 g, 0.094 mmol), Pd\C (10%) (0.025 g), in ethanol (20 ml) were stirred under hydrogen atmosphere for 20 hours. Reaction mixture was filtered through celite bed washed with methanol (20 ml), and the solvents were removed under vacuum. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 2 to 4% methanol in DCM as an eluent to obtain 8-(1-Benzyl-1H-pyrazol-4-yl)-1-propyl-1,7-dihydro-purin-6-one (0.012 g, 39%) as off white solid.

1. customReaction mixture
2. filtrationwas filtered through celite bed
3. washwashed with methanol (20 ml)
4. customthe solvents were removed under vacuum
5. customThe crude product was purified by column chromatography