HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → Methyl 6-amino-2,3,4-trimethoxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Reactant | 6-Amino-2,3,4-trimethoxybenzoic acid | HCID 13036392 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Methyl 6-amino-2,3,4-trimethoxybenzoate | HCID 606724 | 99% |
Reaction Steps
A solution of 6-amino-2,3,4-tris(methyloxy)benzoic acid (2.7 g, 11.88 mmol) in THF (20 mL) and MeOH (20 mL) at 25° C. was treated with a solution of 2M TMS-diazomethane in Et2O (14.85 mL, 29.7 mmol) and stirred for 10 minutes before being concentrated to give methyl 6-amino-2,3,4-tris(methyloxy)benzoate (2.87 g, 99%) as a brown solid. MS (m/z) 242.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859571B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-0ea60f2d625c4af5a23ce63fd8defe54 |
| Source note | uspto-grants-2014_10 |