4-Chloro-5,7-dimethoxyquinazoline → HCID 68194054, compound

Participants

Reaction Steps

A mixture of 4-chloro-5,7-bis(methyloxy)quinazoline (75 mg, 0.334 mmol, prepared according to J. Med. Chem. (2006) 49 6465) and 3-amino-N-methyl-4-[(2,2,2-trifluoroethyl)oxy]benzenesulfonamide (95 mg, 0.334 mmol) in i-PrOH (2 mL) was subjected to microwave irradiation (100° C., 1 bar) for 30 minutes before being cooled to room temperature. The solid was collected by filtration, washed with i-PrOH, and dried under vacuum to give 3-{[5,7-bis(methyloxy)-4-quinazolinyl]amino}-N-methyl-4-[(2,2,2-trifluoroethyl)oxy]benzenesulfonamide hydrochloride (130 mg, 76%) as a yellow soid.

Provenance & Evidence