HCID 69934912, compound → HCID 52932687, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-(dimethylamino)-N-methyl-3-((6-nitroquinazolin-4-yl)amino)benzene-sulfonamide (715 mg, 1.78 mmol) in MeOH (50 mL) was treated with 10% Pd/C (189 mg, 0.178 mmol) and stirred under H2 (balloon) at 25° C. for 2.5 hours before being filtered through celite and concentrated. The residue was dissolved in CH2Cl2/MeOH, washed with saturated aqueous NaHCO3, dried (Na2SO4), and concentrated to give 3-((6-aminoquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide (433 mg, 59%) as a yellow solid.

Provenance & Evidence