Potassium Carbonate → HCID 86623125, compound

Participants

Reaction Conditions

Reaction Steps

1-Iodopropane (3.09 mL, 31.60 mmol) was added to a solution of 3-hydroxy-2-(2-methoxyethoxy)benzaldehyde (3.1 g, 15.8 mmol) and potassium carbonate (4.37 g, 31.60 mmol) in DMF (80 mL) and the mixture was stirred at 100° C. overnight under a nitrogen atmosphere. The reaction mixture was partitioned between saturated ammonium chloride (aq.) and CH2Cl2. The organic phase was washed with brine, dried (Na2SO4) and concentrated to give the title compound in quantitative yield (3.8 g) as an oil. This material was used in the next step without further purification.

Provenance & Evidence