Ethyl isothiocyanatoformate → AZD 3241

HRID 536085Notes

Reaction equation

C(O[C:4]([C:6]1[NH:7][CH:8]=[CH:9][C:10]=1[NH:11][CH2:12][CH2:13][O:14][CH:15]([CH3:17])[CH3:16])=[O:5])C.C(OC([N:23]=[C:24]=[S:25])=O)C>>[CH:15]([O:14][CH2:13][CH2:12][N:11]1[C:10]2[CH:9]=[CH:8][NH:7][C:6]=2[C:4](=[O:5])[NH:23][C:24]1=[S:25])([CH3:16])[CH3:17]

Participants

Reactant 2

HCID 85320Ethyl isothiocyanatoformate

HCID 67068496HCID 67068496, compound

Product 1

HCID 11528958AZD 3241Yield 23.1%

Procedure

The title compound (0.17 g, 23%) was prepared in accordance with the general method B using 3-[(2-isopropoxyethyl)amino]-1H-pyrrole-2-carboxylic acid ethyl ester (0.7 g, 2.91 mmol) and ethoxycarbonyl isothiocyanate (0.40 mL, 3.50 mmol).

Sources & evidence

ORD record: ord-807df30b66224bcb8b8da8a0112c6c9f
Source dataset: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08859568B2

Reaction notes

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