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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 536096Generated: October 30, 2026

Acetic Acid → HCID 67068493, compound

https://huagongshe.com/reaction/536096

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantIndole-3-CarboxaldehydeHCID 10256—
ReactantEthyl 3-amino-1H-pyrrole-2-carboxylateHCID 2773439—
ReactantSodium cyanoborohydrideHCID 5003444—
SolventMethanolHCID 887—
ProductHCID 67068493HCID 67068493—

Reaction Steps

A reaction mixture of 3-amino-1H-pyrrole-2-carboxylic acid ethyl ester (0.075 g, 0.49 mmol), indole-3-carboxaldehyde (0.085 g, 0.58 mmol), NaCNBH3 (0.031 g, 0.49 mmol) and HOAc (0.056 mL, 0.97 mmol) in methanol (3 mL) was stirred at r.t. overnight. The mixture was concentrated in vacuo and the crude product-mixture was used in the next step without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08859568B2
Source datasetuspto-grants-2014_10
ORD IDord-4e07a3aec3554498b56e1a0ae7bc7275
Source noteuspto-grants-2014_10