反应详情

温度

45 °C

To a stirred solution of the product from Example 8.1 (800 mg, 2.56 mmol) in methanol (30 mL), was added hydrazine (6.0 eq) at room temperature. The mixture was then heated at 45° C. for 4 h then partially concentrated in vacuo (not to dryness), then cooled to room temperature. The resulting solid was filtered, washed with water and dried under vacuum to afford the desired compound (650 mg, yield 78%).

1. concentrationthen partially concentrated in vacuo (not to dryness),
2. temperaturethen cooled to room temperature
3. filtrationThe resulting solid was filtered
4. washwashed with water
5. customdried under vacuum