Tetrahydrofuran → HCID 86689892, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-2-pyridinecarbonitrile (0.876 g, 2.93 mmol) in anhydrous tetrahydrofuran (30 mL), was added DIBAL-H (5.87 mL, 5.87 mmol) dropwise at −78° C. The reaction mixture was stirred for 1 h at −78° C., then quenched with 1N HCl solution, concentrated. Purification via ISCO afforded the title product (350 mg) as an off white solid. LC-MS (ESI): m/z 302 [M+H]+; 3.47 min (ret time).

Provenance & Evidence