反应详情

A suspension 2-chloro-5-(dibromomethyl)-3-fluoropyridine (2.3 g, 7.58 mmol), silver nitrate (5.15 g, 30.3 mmol) in a mixed solvents of ethanol (10 mL) and water (10 mL) was stirred for 1 h at 100° C., then filtrated, and concentrated. The residue was dissolved in ethyl acetate, washed with water and brine, dried over sodium sulfate, concentrated. Purification via ISCO system afforded the title product (1.0 g) as a pale solid. LC-MS (ESI): m/z 159 [M+H]+; 2.01 min (ret time).

1. filtrationfiltrated
2. concentrationconcentrated
3. dissolutionThe residue was dissolved in ethyl acetate
4. washwashed with water and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customPurification via ISCO system