Sodium borohydride → (4-(3-(Trifluoromethyl)phenoxy)phenyl)methanol

Participants

Reaction Steps

A solution of 4-{[3-(Trifluoromethyl)phenyl]oxy}benzaldehyde (4.1 g, 9.55 mmol) in methanol (50 mL) at 0° C. was added sodium borohydride (1.0 g, 26.4 mmol) in portions. The reaction mixture was allowed to warm to rt and stirred for 1 h, then quenched with acetone, concentrated. Purification via ISCO system afforded the title product (3.11 g) as a colorless liquid. LC-MS (ESI): m/z 251 [M-OH]+; 3.23 min (ret time).

Provenance & Evidence