HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Ethyl 3-pyridylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 3-Pyridineacetic acid, hydrochloride (1:1) | HCID 2723724 | — |
| Product | Ethyl 3-pyridylacetate | HCID 96490 | — |
Reaction Steps
To a solution of 3-pyridylacetic acid hydrochloride (40 g, 230.41 mmol) in ethanol (90 mL) was added sulfuric acid (73 g, 744.3 mmole, 98%) under N2. The reaction mixture was refluxed for 4 h, then cooled to rt. Ammonium hydroxide (250 mL, 25%) was added and extracted with DCM (500 mL) twice, dried over sodium sulfate, concentrated to afford the title product (33 g),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08859573B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-1d90bed7f1274cdc9941c8ccd1b71cce |
| Source note | uspto-grants-2014_10 |