Tyrosol → 2-(4-(5-(Trifluoromethyl)-2-pyridinyloxy)phenyl)ethanol

HRID 536177Notes

Reaction equation

HRID 536177 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.Cl[C:12]1[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][N:13]=1>>[F:19][C:18]([F:21])([F:20])[C:15]1[CH:16]=[CH:17][C:12]([O:10][C:7]2[CH:8]=[CH:9][C:4]([CH2:3][CH2:2][OH:1])=[CH:5][CH:6]=2)=[N:13][CH:14]=1

Participants

3

Reactant 2

HCID 10393TyrosolHCID 923422-Chloro-5-(trifluoromethyl)pyridine

Product 1

HCID 190175502-(4-(5-(Trifluoromethyl)-2-pyridinyloxy)phenyl)ethanol

Procedure

The title compound was prepared by a procedure similar to that described for D3 starting from 4-(2-hydroxyethyl)phenol and 2-chloro-5-(trifluoromethyl)pyridine. LC-MS (ESI): m/z 284 [M+H]+; 2.97 min (ret time).

Workup

  1. custom2.97 min (ret time)

Sources & evidence

ORD record
ord-cc6390d4d5c84c9dbd6c7c6c3013f875
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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