3-(Chloromethyl)pyridine hydrochloride → 2-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(3-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile

Participants

Role	Name	HCID	Charge
Reactant	3-(Chloromethyl)pyridine hydrochloride	HCID 23394	—
Reactant	2-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-1,2-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile	HCID 57383181	—
Product	2-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}-5-({[2-oxo-1-(3-pyridinylmethyl)-1,2-dihydro-4-pyrimidinyl]oxy}methyl)benzonitrile	HCID 57379014	—

Reaction Steps

The title compound was prepared by a procedure similar to that described for E1 starting from 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-2,3-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile and 3-(chloromethyl)pyridine hydrochloride. LC-MS (ESI): m/z 513 [M+H]+; 2.94 min (ret time).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08859573B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-b9186a93282d42b1acde33c32726c87d
Source note	uspto-grants-2014_10