4-(Chloromethyl)-1-methylpyrazole Hydrochloride → HCID 67960654, compound

HRID 536185Notes

Reaction equation

HRID 536185 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][NH:22][C:21](=[O:25])[N:20]=3)=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:26]([F:29])([F:28])[F:27].Cl.Cl[CH2:32][C:33]1[CH:34]=[N:35][N:36]([CH3:38])[CH:37]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:16]=[CH:15][C:14]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][N:22]([CH2:32][C:33]4[CH:34]=[N:35][N:36]([CH3:38])[CH:37]=4)[C:21](=[O:25])[N:20]=3)=[CH:13][C:10]=2[C:11]#[N:12])=[CH:4][C:3]=1[C:26]([F:27])([F:29])[F:28]

Participants

3

Reactant 2

HCID 567737394-(Chloromethyl)-1-methylpyrazole HydrochlorideHCID 178510084HCID 178510084, compound

Product 1

HCID 67960654HCID 67960654, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 2-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-{[(2-oxo-1,2-dihydro-4-pyrimidinyl)oxy]methyl}benzonitrile and 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride. LC-MS (ESI): m/z 514 [M+H]+; 3.97 min (ret time).

Workup

  1. custom3.97 min (ret time)

Sources & evidence

ORD record
ord-a71b21cb1e064a6990f530c360583341
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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