4-(Chloromethyl)-1-methylpyrazole Hydrochloride → HCID 67960193, compound

HRID 536186Notes

Reaction equation

HRID 536186 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][NH:20][C:19](=[O:23])[N:18]=3)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:24]([F:27])([F:26])[F:25].Cl.Cl[CH2:30][C:31]1[CH:32]=[N:33][N:34]([CH3:36])[CH:35]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][N:20]([CH2:30][C:31]4[CH:32]=[N:33][N:34]([CH3:36])[CH:35]=4)[C:19](=[O:23])[N:18]=3)=[CH:13][CH:14]=2)=[CH:4][C:3]=1[C:24]([F:25])([F:27])[F:26]

Participants

3

Reactant 2

HCID 567737394-(Chloromethyl)-1-methylpyrazole HydrochlorideHCID 178518418HCID 178518418, compound

Product 1

HCID 67960193HCID 67960193, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 4-{[(4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]oxy}-2(1H)-pyrimidinone and 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride. LC-MS (ESI): m/z 491 [M+H]+; 3.49 min (ret time).

Workup

  1. custom3.49 min (ret time)

Sources & evidence

ORD record
ord-c809417b6af24571ba11b86e54537e6e
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

Loading…