3-(Chloromethyl)pyridine hydrochloride → HCID 57383186, compound

HRID 536191Notes

Reaction equation

HRID 536191 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]3[NH:22][C:21](=[O:23])[N:20]=[CH:19][CH:18]=3)=[N:13][CH:14]=2)=[CH:4][C:3]=1[C:24]([F:27])([F:26])[F:25].Cl.Cl[CH2:30][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[CH:11][C:12]([CH2:15][O:16][C:17]3[CH:18]=[CH:19][N:20]([CH2:30][C:31]4[CH:32]=[N:33][CH:34]=[CH:35][CH:36]=4)[C:21](=[O:23])[N:22]=3)=[N:13][CH:14]=2)=[CH:4][C:3]=1[C:24]([F:25])([F:26])[F:27]

Participants

3

Reactant 2

HCID 233943-(Chloromethyl)pyridine hydrochlorideHCID 67958236HCID 67958236, compound

Product 1

HCID 57383186HCID 57383186, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 6-{[(5-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-2-pyridinyl)methyl]oxy}-2(1H)-pyrimidinone and 3-(chloromethyl)pyridine hydrochloride. LC-MS (ESI): m/z 489 [M+H]+; 2.67 min (ret time).

Workup

  1. custom2.67 min (ret time)

Sources & evidence

ORD record
ord-845201644c2d4a9396a86e969ef6907a
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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