4-(Chloromethyl)-1-methylpyrazole Hydrochloride → HCID 57383225, compound

HRID 536194Notes

Reaction equation

HRID 536194 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[N:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][C:18]3[NH:23][C:22](=[O:24])[N:21]=[CH:20][CH:19]=3)=[CH:11][C:10]=2[F:25])=[CH:4][C:3]=1[C:26]([F:29])([F:28])[F:27].Cl.Cl[CH2:32][C:33]1[CH:34]=[N:35][N:36]([CH3:38])[CH:37]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[N:14]=[CH:13][C:12]([CH2:15][CH2:16][O:17][C:18]3[CH:19]=[CH:20][N:21]([CH2:32][C:33]4[CH:34]=[N:35][N:36]([CH3:38])[CH:37]=4)[C:22](=[O:24])[N:23]=3)=[CH:11][C:10]=2[F:25])=[CH:4][C:3]=1[C:26]([F:29])([F:27])[F:28]

Participants

3

Reactant 2

HCID 567737394-(Chloromethyl)-1-methylpyrazole HydrochlorideHCID 67966670HCID 67966670, compound

Product 1

HCID 57383225HCID 57383225, compound

Procedure

The title compound was prepared by a procedure similar to that described for E1 starting from 6-{[2-(6-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}-5-fluoro-3-pyridinyl)ethyl]oxy}-2 (1H)-pyrimidinone and 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride. LC-MS (ESI): m/z 524 [M+H]+; 3.36 min (ret time).

Workup

  1. custom3.36 min (ret time)

Sources & evidence

ORD record
ord-8ce50eff11534ac0a5dbba18fd9253ac
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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