4-(Chloromethyl)-1-methylpyrazole Hydrochloride → HCID 67960262, compound

HRID 536196Notes

Reaction equation

HRID 536196 reaction equation
[O:1]=[C:2]1[N:7]=[C:6]([CH2:8][CH2:9][C:10]2[CH:11]=[CH:12][C:13]([O:18][C:19]3[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=3)=[C:14]([CH:17]=2)[C:15]#[N:16])[CH:5]=[CH:4][NH:3]1.Cl.Cl[CH2:31][C:32]1[CH:33]=[N:34][N:35]([CH3:37])[CH:36]=1>>[CH3:37][N:35]1[CH:36]=[C:32]([CH2:31][N:3]2[CH:4]=[CH:5][C:6]([CH2:8][CH2:9][C:10]3[CH:11]=[CH:12][C:13]([O:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:26])[F:27])[CH:20]=4)=[C:14]([CH:17]=3)[C:15]#[N:16])=[N:7][C:2]2=[O:1])[CH:33]=[N:34]1

Participants

3

Reactant 2

HCID 567737394-(Chloromethyl)-1-methylpyrazole HydrochlorideHCID 178509692HCID 178509692, compound

Product 1

HCID 67960262HCID 67960262, compound

Procedure

The title compound was prepared with a procedure similar to that described for E1 starting form 5-[2-(2-oxo-1,2-dihydro-4-pyrimidinyl)ethyl]-2-{[3-(trifluoromethyl)phenyl]oxy}-benzonitrile and 4-(chloromethyl)-1-methyl-1H-pyrazole hydrochloride. LC-MS (ESI): m/z 480 [M+H]+; 2.90 min (ret time).

Workup

  1. custom2.90 min (ret time)

Sources & evidence

ORD record
ord-d624b98d7a394c1e9e94fa693cf36400
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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