5-(Chloromethyl)pyrimidine → HCID 67960702, compound

HRID 536201Notes

Reaction equation

HRID 536201 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][NH:20][C:19](=[O:23])[CH:18]=3)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:24]([F:27])([F:26])[F:25].Cl[CH2:29][C:30]1[CH:31]=[N:32][CH:33]=[N:34][CH:35]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][N:20]([CH2:29][C:30]4[CH:31]=[N:32][CH:33]=[N:34][CH:35]=4)[C:19](=[O:23])[CH:18]=3)=[CH:11][CH:10]=2)=[CH:4][C:3]=1[C:24]([F:27])([F:25])[F:26]

Participants

3

Reactant 2

HCID 147202965-(Chloromethyl)pyrimidineHCID 67958516HCID 67958516, compound

Product 1

HCID 67960702HCID 67960702, compound

Procedure

The title compound was prepared by a procedure similar to that described for E21 starting from 4-{[(4-{[4-Chloro-3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]oxy}-2 (1H)-pyridinone and 5-(chloromethyl)pyrimidine. LC-MS (ESI): m/z 488 [M+H]+; 3.57 min (ret time).

Workup

  1. custom3.57 min (ret time)

Sources & evidence

ORD record
ord-6afe18422a244f9d81e49d85e178cd7d
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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