HCID 21698362, compound → 4-[({4-[(3-Fluoro-4-methylphenyl)oxy]phenyl}methyl)oxy]-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2(1H)-pyridinone

HRID 536203Notes

Reaction equation

HRID 536203 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([O:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][NH:21][C:20](=[O:24])[CH:19]=3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH3:8].Cl[CH2:26][C:27]1[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=1>>[F:1][C:2]1[CH:3]=[C:4]([O:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][N:21]([CH2:26][C:27]4[CH:28]=[N:29][N:30]([CH3:32])[CH:31]=4)[C:20](=[O:24])[CH:19]=3)=[CH:12][CH:11]=2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 21698362HCID 21698362, compoundHCID 679602374-[({4-[(3-fluoro-4-methylphenyl)oxy]phenyl}methyl)oxy]-2(1H)-pyridinone

Product 1

HCID 679666814-[({4-[(3-Fluoro-4-methylphenyl)oxy]phenyl}methyl)oxy]-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-2(1H)-pyridinone

Procedure

The title compound was prepared by a procedure similar to that described for E21 starting from 4-[({4-[(3-fluoro-4-methylphenyl)oxy]phenyl}methyl)oxy]-2(1H)-pyridinone and 4-(chloromethyl)-1-methyl-1H-pyrazole. LC-MS (ESI): m/z 420 [M+H]+; 3.35 min (ret time).

Workup

  1. custom3.35 min (ret time)

Sources & evidence

ORD record
ord-b62931f8442f4d2b9bcd23dc5ae04048
Source dataset
uspto-grants-2014_10
Patent number
US08859573B2

Reaction notes

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