4-[(3-Chloropropyl)sulfonyl]morpholine → HCID 178522517, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 1 was used to prepare the title compound from N-(7-hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (Intermediate C) and 4-[(3-chloropropyl)sulfonyl]morpholine (Intermediate E). High vacuum drying at 60° C. gave the title compound (42 mg, 34%): HPLC MS RT=1.82 min, MH+=499.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.26-2.31 (2H, m), 3.13-3.24 (4H, m), 3.37-3.43 (2H, m), 3.60-3.63 (4H, m), 4.27-4.34 (2H, m), 4.43 (2H, t), 4.58-4.65 (2H, m), 7.58 (1H, t), 7.73 (1H, d), 7.84 (1H, d), 7.94 (1H, dd), 8.86 (1H, d), 8.98 (1H, dd), 9.46 (1H, d).

Provenance & Evidence