1-((3-Chloropropyl)sulfonyl)-4-methylpiperazine → HCID 178481109, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 1 was used to prepare the title compound from N-(7-hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (Intermediate C) and 1-[(3-chloropropyl)sulfonyl]-4-methylpiperazine (Intermediate D). High vacuum drying at 60° C. gave the title compound (72 mg, 57%): HPLC MS RT=1.22 min, MH+=512.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.26-2.31 (2H, m), 2.82 (3H, s), 3.11-3.21 (4H, m), 3.45-3.50 (4H, m), 3.83-3.87 (2H, m), 4.27-4.34 (2H, m), 4.42 (2H, t), 4.58-4.65 (2H, m), 7.60 (1H, t), 7.73 (1H, d), 7.85 (1H, d), 7.94 (1H, dd), 8.86 (1H, d), 9.00 (1H, dd), 9.48 (1H, d).

Provenance & Evidence