反应详情

温度

25 °C

A mixture of 64.2 mg (0.20 mmol) of 2-amino-6-(2,6-dichlorophenyl)-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one (from Example 12) and 1 mL of acetic anhydride was heated to reflux. The resulting solution was maintained at reflux for 20 minutes and concentrated at atmospheric pressure to about 0.25 mL volume. The solution was cooled to 25° C. and diluted with diethyl ether (1 mL). The separated crystals were filtered and washed with diethyl ether to provide N-[6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidin-2-yl]acetamide, wt 44.0 mg; mp 258°-260° C.; MS (CI) 363 (M+ +1).

1. temperaturewas heated to reflux
2. temperatureThe resulting solution was maintained
3. temperatureat reflux for 20 minutes
4. concentrationconcentrated at atmospheric pressure to about 0.25 mL volume
5. additiondiluted with diethyl ether (1 mL)
6. filtrationThe separated crystals were filtered
7. washwashed with diethyl ether