1-(Chloromethyl)-4-methanesulfonylbenzene → HCID 178504766, compound

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Reaction Steps

The procedure used for the preparation of Example 1 was used to prepare the title compound from N-(7-hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (Intermediate C) and 1-(chloromethyl)-4-(methylsulfonyl)benzene. High vacuum drying at 60° C. gave the title compound (50 mg, 43%): HPLC MS RT=2.05 min, MH+=476.1; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 3.24 (3H, s), 4.28-4.34 (2H, m), 4.59-4.66 (2H, m), 5.62 (2H, s), 7.61 (1H, t), 7.79-7.88 (4H, m), 7.98-8.05 (3H, m), 8.98-9.02 (2H, m), 9.53 (1H, s).

Provenance & Evidence