反应详情

The procedure used for the preparation of Example 1 was used to prepare the title compound from N-[7-hydroxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]nicotinamide (Intermediate H) and 1-[(3-chloropropyl)sulfonyl]-4-methylpiperazine (Intermediate D). High vacuum drying gave the title compound (29 mg, 27%): HPLC MS RT=0.23 min, MH+=655.6; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.22-2.27 (4H, m), 2.82 (3H, s), 3.09-3.18 (6H, m), 3.29-3.32 (2H, m), 3.45-3.52 (6H, m), 3.64-3.70 (2H, m), 3.77-3.80 (2H, m), 3.99-4.01 (2H, m), 4.24-4.29 (2H, m), 4.32-4.36 (4H, m), 4.55-4.60 (2H, m), 7.49 (1H, d), 7.90 (1H, dd), 8.09 (1H, d), 8.83 (1H, d), 8.98 (1H, dd), 9.47 (1H, d).

1. customThe procedure used for the preparation of Example 1