1-(Chloromethyl)-4-methanesulfonylbenzene → HCID 178493824, compound

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Reaction Steps

The procedure used for the preparation of Example 1 was used to prepare the title compound from 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol bistrifluoroacetate salt (Intermediate A) and 1-(chloromethyl)-4-(methylsulfonyl)benzene. High vacuum drying gave the title compound (970 mg, 56%): HPLC MS RT=1.59 min, MH+=401.1; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 3.21 (3H, s), 3.85 (3H, s), 4.16-4.19 (2H, m), 4.32-4.35 (2H, m), 5.47 (2H, s), 7.36 (1H, d), 7.74 (2H, d), 7.88 (1H, d), 7.97 (2H, d).

Provenance & Evidence