3-chloro-N,N-dimethylpropane-1-sulfonamide → 3-[(5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl)oxy]-N,N-dimethylpropane-1-sulfonamide

Participants

Reaction Steps

The procedure used for the preparation of Example 1 was used to prepare the title compound from 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol bistrifluoroacetate salt (Intermediate A) and 3-chloro-N,N-dimethylpropane-1-sulfonamide (Intermediate F). High vacuum drying gave the title compound (1.12 g, 86%): HPLC MS RT=1.28 min, MH+=382.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.15-2.20 (2H, m), 2.77 (6H, s), 3.18-3.23 (2H, m), 3.84 (3H, s), 4.18-4.21 (2H, m), 4.29-4.35 (4H, m), 7.30 (1H, d), 7.90 (1H, d).

Provenance & Evidence