2-aminopyrimidine-5-carboxylic Acid → HCID 178493875, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 3-[(5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl)oxy]-N,N-dimethylpropane-1-sulfonamide (Step 1) and 2-aminopyrimidine-5-carboxylic acid. High vacuum drying gave the title compound (261 mg, 79%): HPLC MS RT=2.09 min, MH+=503.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.20-2.25 (2H, m), 2.78 (6H, s), 3.20-3.25 (2H, m), 3.99 (3H, s), 4.18-4.25 (2H, m), 4.37 (2H, t), 4.48-4.55 (2H, m), 7.44 (1H, d), 8.02 (1H, d), 9.07 (2H, s).

Provenance & Evidence