反应详情

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 3-[(5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl)oxy]-N,N-dimethylpropane-1-sulfonamide (Example 17 Step 1) and 6-aminonicotinic acid. High vacuum drying gave the title compound (117 mg, 59%): HPLC MS RT=1.60 min, MH+=502.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.19-2.24 (2H, m), 2.78 (6H, s), 3.19-3.24 (2H, m), 3.99 (3H, s), 4.20-4.26 (2H, m), 4.37 (2H, t), 4.47-4.54 (2H, m), 7.04 (1H, d), 7.46 (1H, d), 8.03 (1H, d), 8.48 (1H, dd), 8.77 (1H, d).

1. customThe procedure used for the preparation of Example 16, Step 2