4-(3-Hydroxypropyl)thiomorpholine 1,1-Dioxide → 8-[3-(1,1-dioxo-1,4-thiazinan-4-yl)propoxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine

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Reaction Steps

The procedure used for the preparation of Example 4 was used to prepare the title compound from 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol bistrifluoroacetate salt (Intermediate A) and 3-(1,1-dioxidothiomorpholin-4-yl)propan-1-ol. High vacuum drying gave the title compound (1.48 g, 83%): HPLC MS RT=0.26 min, MH+=408.3; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.23-2.25 (2H, m), 3.43-3.48 (2H, m), 3.81-3.84 (7H, m), 4.19-4.22 (2H, m), 4.27 (2H, t), 4.33-4.36 (2H, m), 7.30 (1H, d), 7.92 (1H, d).

Provenance & Evidence