6-Aminonicotinic acid → HCID 178493822, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 7-methoxy-8-{[4-(methylsulfonyl)benzyl]oxy}-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (Example 16 Step 1) and 6-aminonicotinic acid. High vacuum drying gave the title compound (151 mg, 77%): HPLC MS RT=2.00 min, MH+=521.1; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 3.24 (3H, s), 4.02 (3H, s), 4.23-4.28 (2H, m), 4.50-4.55 (2H, m), 5.56 (2H, s), 7.06 (1H, d), 7.58 (1H, d), 7.79 (2H, d), 8.01 (1H, d), 8.05 (1H, d), 8.50 (1H, dd), 8.79 (1H, d).

Provenance & Evidence