2-aminopyrimidine-5-carboxylic Acid → HCID 178493864, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 8-[3-(1,1-dioxidothiomorpholin-4-yl)propoxy]-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (Example 19, Step 1) and 2-aminopyrimidine-5-carboxylic acid. High vacuum drying at 60° C. gave the title compound (272 mg, 79%): HPLC MS RT=1.45 min, MH+=529.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.25-2.30 (2H, m), 3.44-3.49 (2H, m), 3.61-3.63 (4H, m), 3.83 (4H, bs), 3.99 (3H, s), 4.18-4.25 (2H, m), 4.33 (2H, t), 4.48-4.55 (2H, m), 7.43 (1H, d), 8.02 (1H, d), 9.04 (2H, s).

Provenance & Evidence