4-[(3-Chloropropyl)sulfonyl]morpholine → HCID 178493873, compound

HRID 536253Notes

Reaction equation

HRID 536253 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[N:14]([CH2:22][CH2:23][N:24]=3)[C:15]([NH2:21])=[N:16][C:17]=2[C:18]=1[O:19][CH3:20])[C:2]1[CH:7]=CC=CC=1.ClCCC[S:29]([N:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1)(=[O:31])=[O:30]>>[CH3:20][O:19][C:18]1[C:17]2[N:16]=[C:15]([NH2:21])[N:14]3[CH2:22][CH2:23][N:24]=[C:13]3[C:12]=2[CH:11]=[CH:10][C:9]=1[O:8][CH2:1][CH2:2][CH2:7][S:29]([N:32]1[CH2:37][CH2:36][O:35][CH2:34][CH2:33]1)(=[O:31])=[O:30]

Participants

3

Reactant 2

HCID 2844074-[(3-Chloropropyl)sulfonyl]morpholine2×HCID 1784938207-methoxy-8-phenylmethoxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine2×

Product 1

HCID 178493873HCID 178493873, compound

Procedure

The procedure used for the preparation of Example 1 was used to prepare the title compound from 5-amino-7-methoxy-2,3-dihydroimidazo[1,2-c]quinazolin-8-ol bistrifluoroacetate salt (Intermediate A) and 4-[(3-chloropropyl)sulfonyl]morpholine (Intermediate E). High vacuum drying gave the title compound (100%): 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.17-2.22 (2H, m), 3.14-3.17 (4H, m), 3.22-3.27 (2H, m), 3.61-64 (4H, m), 3.83 (3H, s), 4.16-4.20 (2H, m), 4.28-4.35 (4H, m), 7.30 (1H, d), 7.89 (1H, d).

Workup

  1. customThe procedure used for the preparation of Example 1

Sources & evidence

ORD record
ord-158cb9a00ce647f9befbbab20cdb2642
Source dataset
uspto-grants-2014_10
Patent number
US08859572B2

Reaction notes

Loading…