反应详情

The procedure used for the preparation of Example 16, Step 2 was used to prepare the title compound from 7-methoxy-8-[3-(morpholin-4-ylsulfonyl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (Step 1) and 6-aminonicotinic acid. High vacuum drying gave the title compound (122 mg, 63%): HPLC MS RT=1.96 min, MH+=544.2; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.22-2.27 (2H, m), 3.15-3.18 (4H, m), 3.24-3.29 (2H, m), 3.61-3.65 (4H, m), 3.99 (3H, s), 4.24-4.27 (2H, m), 4.38 (2H, t), 4.48-4.52 (2H, m), 7.05 (1H, d), 7.47 (1H, d), 8.04 (1H, d), 8.49 (1H, dd), 8.78 (1H, d).

1. customThe procedure used for the preparation of Example 16, Step 2