1-((3-Chloropropyl)sulfonyl)-4-methylpiperazine → HCID 178481108, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 24 was used to prepare the title compound from N-(8-hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (Example 2-5 in WO2004029055) and 1-[(3-chloropropyl)sulfonyl]-4-methylpiperazine (Intermediate D) (70 mg, 16%). TLC: Rf=0.08 in 10% MeOH/CH2Cl2, HPLC MS RT=1.06 min, MH+=512.1; 1H NMR (DMSO-d6) δ: 2.12-2.37 (2H, m), 2.37 (3H, s), 3.15-3.23 (6H, m), 3.30-3.33 (4H, m), 4.00-4.20 (6H, m), 6.84 (1H, d), 7.29 (1H, s), 7.51 (1H, dd), 7.75 (1H, d), 8.41 (1H, d), 8.70 (1H, m), 9.28 (1H, s), 12.29 (1H, s).

Provenance & Evidence