1-(Chloromethyl)-4-methanesulfonylbenzene → HCID 178504765, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 24 was used to prepare the title compound from N-(8-hydroxy-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)nicotinamide (Example 2-5 in WO2004029055) and 1-(chloromethyl)-4-(methylsulfonyl)benzene (20 mg, 4%). TLC: Rf=0.91 in 10% MeOH/CH2Cl2, HPLC MS RT=1.91 min, MH+=476.2; 1H NMR (DMSO-d6) δ: 3.22 (3H, s), 4.00-4.15 (4H, m), 5.33 (2H, s), 6.93 (1H, d), 7.39 (1H, s), 7.51 (1H, dd), 7.71 (2H, d), 7.78 (1H, d), 7.95 (2H, d), 8.42 (1H, d), 8.70 (1H, m), 9.29 (1H, s), 12.31 (1H, s).

Provenance & Evidence