反应详情

The procedure used for the preparation of Example 28, Step 2 was used to prepare the title compound from 8-[3-(morpholin-4-ylsulfonyl)propoxy]-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine (Example 28, Step 1) and 2-aminopyrimidine-5-carboxylic acid. Yield 150 mg (45%). TLC Rf=0.47 in 10% MeOH/CH2Cl2, HPLC MS RT=0.76 min, MH+=515.4; 1H NMR (DMSO-d6) δ: 2.24 (2H, m), 3.21 (4H, m), 3.29 (2H, m), 3.67 (4H, m), 4.20 (2H, t), 4.30 (2H, t), 4.53 (2H, t), 7.20 (1H, d), 7.70 (1H, br s), 7.97 (1H, s), 8.13 (1H, d), 9.02 (2H, s).

1. customThe procedure used for the preparation of Example 28, Step 2