HCID 178493909, compound → HCID 178493908, compound

Participants

Reaction Steps

tert-Butyl {2-[2-({7-methoxy-5-[(pyridin-3-ylcarbonyl)amino]-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl}oxy)ethoxy]ethyl}carbamate (Step 3, 3.6 g, 6.8 mmol) was diluted in a mixture of trifluoroacetic acid (18 mL) and dichloromethane (70 mL). The mixture was stirred at rt overnight, then was concentrated in vacuo. The resultant orange oil was redissolved in dichloromethane and treated with an excess of triethylamine. After stirring at rt for 0.5 h, the solvent was evaporated under reduced pressure and the residue triturated with ethyl acetate. The title compound was isolated by vacuum filtration and dried in the vacuum oven. This material was contaminated with a small amount of triethylamine, but was suitable for use in the next step as is. HPLC MS RT=1.09 min, MH+=425.2. 1H NMR (DMSO-d6+2 drops TFA-d) δ: 3.01 (2H, m), 3.69 (2H, t), 3.89 (2H, m), 4.02 (3H, s), 4.26 (2H, m), 4.44 (2H, m), 4.57 (2H, m), 7.49 (1H, d), 7.76 (1H, m), 8.05 (1H, d), 8.72 (1H, m), 8.89 (1H, m), 9.44 (1H, m).

Provenance & Evidence