Acetonitrile → HCID 178493868, compound

Participants

Reaction Steps

tert-Butyl[3-({7-methoxy-5-[(pyridin-3-ylcarbonyl)amino]-2,3-dihydroimidazo[1,2-c]quinazolin-8-yl}oxy)propyl]carbamate (Step 1, 1.2 g, 2.3 mmol) was diluted in a mixture of trifluoroacetic acid (6 mL) and dichloromethane (24 mL). The mixture was stirred at rt overnight, then was concentrated in vacuo to afford a viscous yellow oil. Acetonitrile was added to the mixture, and the desired was isolated by vacuum filtration as a white solid (0.55 g, 60%). 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.13 (2H, m), 3.02 (2H, m), 4.01 (3H, s), 4.25 (2H, m), 4.35 (2H, t), 4.57 (2H, m), 7.45 (1H, d), 7.73 (1H, m), 7.92 (2H, br m), 8.06 (1H, d), 8.69 (1H, m), 8.87 (1H, m), 9.43 (1H, m).

Provenance & Evidence