Methanesulfonyl chloride → HCID 178505248, compound

Participants

Reaction Steps

The procedure used for the preparation of Example 36 was used to prepare the title compound from N-[7-hydroxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]nicotinamide (Intermediate H) and methanesulfonyl chloride (58 mg, 49%). TLC: Rf=0.38 in 10% MeOH/CH2Cl2, HPLC MS RT=2.05 min, [M+Na]+=551; 1H NMR (DMSO-d6+2 drops TFA-d) δ: 2.18-2.30 (2H, m), 3.03-3.17 (2H, m), 3.28-3.37 (2H, m), 3.44-3.54 (2H, m), 3.60-3.75 (5H, m), 3.95-4.05 (2H, m), 4.19-4.29 (2H, m), 4.40 (2H, t), 4.56-4.66 (2H, m), 7.63 (1H, d), 7.82 (1H, dd), 8.29 (1H, d), 8.64 (1H, d), 8.93 (1H, dd), 9.35 (1H, s).

Provenance & Evidence