反应详情

To a solution of (2S,3′S)-2-methyl-1′-(6-methyl-5-nitro-pyridin-2-yl)-[1,3′]bipyrrolidinyl (0.633 g, 2.18 mmol) in methanol (60 mL) in a 250 mL parr shaker bottle was added 5% Pd/C (0.200 g). The reaction mixture was allowed to shake under a hydrogen atmosphere (55 psi) at room temperature for 4 hours. The reaction mixture was filtered through a pad of Celite and the filtrate was concentrated under vacuum to afford 0.544 g (96%) of title compound.

1. customat room temperature
2. customfor 4 hours
3. filtrationThe reaction mixture was filtered through a pad of Celite
4. concentrationthe filtrate was concentrated under vacuum