Sodium Hydroxide → HCID 178484831, compound

Participants

Reaction Conditions

Reaction Steps

To the stirred solution of (trans)-(4-amino-cyclohexyl)-carbamic acid tert-butyl ester (4.29 g, 20.0 mmol) in THF (160 ml) (under argon atmosphere) was added LiAlH4 (3.13 g, 80 mmol) in three portions, at 0-5° C. The suspension was heated to 70° C. and stirred for additional 18 h. The reaction mixture was cooled to 0° C. and then subsequently addition of THF-H2O 1:1 (4 ml), 4M NaOH (8 ml) and water (12 ml). Stirring was continued for 3 h at RT. The white suspension was filtered (Celite) and the filtrate was concentrated in vacuo to get the crude title compound as a slightly yellow liquid. This material was used for the next step without further purifications.

Provenance & Evidence