HCID 71145828, compound → HCID 71145623, compound

Participants

Reaction Steps

To the stirred solution of Example 15 (100 mg, 0.211 mmol) in THF (1.05 ml) was added methylmagnesium bromide (3M in diethyl ether) (0.126 ml, 0.329 mmol) during 2 min at −15° C. Stirring was continued for 2 h at RT and then quenched with 1M NH4Cl. The mixture was extracted with EtOAc (2×). The organic phases were washed with brine and dried over Na2SO4, filtered and evaporated to dryness. The resulting crude material was purified by reverse phase prep-HPLC (Waters system) to yield the title compound as a beige foam (17 mg, 0.035 mmol, 17%). HPLC: BtRet=5.71; LC-MS: m/z 486.3 [M+H]+.

Provenance & Evidence