HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 536343Generated: October 30, 2026
Methyl iodide → 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide
https://huagongshe.com/reaction/536343
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 5-Methyl-2-isopropyloxy-4-(pyridine-4-YL)-nitrobenzene | HCID 59764545 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide | HCID 67071170 | — |
Reaction Steps
4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-pyridine (Step 3, 217 mg, 0.797 mmol) was dissolved in anhydrous THF (9 mL). Iodomethane (0.10 mL, 1.61 mmol, 2 equiv.) was added, and the reaction was stirred at 40° C. in a sealed tube for 2 days. The volatiles were removed under vacuum, generating 4-(5-Isopropoxy-2-methyl-4-nitro-phenyl)-1-methyl-pyridinium iodide as a brown solid: ESMS m/z 287.1 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08859574B2 |
|---|
| Source dataset | uspto-grants-2014_10 |
|---|
| ORD ID | ord-d054cfcec724423b86501085de2c7448 |
|---|
| Source note | uspto-grants-2014_10 |
|---|
