Dimethylformamide → HCID 58524136, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-methylbenzotriazole-7-carboxylic acid (0.1 g) in dimethyl formamide (20 ml) was treated with cesium carbonate (0.37 g) and methyl iodide (0.1 ml) stirred at 50° C. for 5 h. The reaction mixture was quenched with water (10 ml) and extracted with ethyl acetate (3×5 ml). The combined organic layers were dried over sodium sulfate and concentrated. Chromatographic purification (hexane/ethyl acetate 85:15) gave 1,4-dimethylbenzotriazole-7-carboxylic acid methyl ester (30 mg) and 2,4-dimethylbenzotriazole-7-carboxylic acid methyl ester (26 mg).

Provenance & Evidence