Isopropanol → HCID 136351080, compound

Participants

Reaction Steps

A solution of 4-formyl-1-methylbenzotriazole-7-carboxylic acid methyl ester (0.15 g) in isopropyl alcohol (10 ml) and water (5 ml) was treated with hydroxylamine hydrochloride (0.05 g) and sodium acetate (0.06 g) and stirred for 2 h. Isopropyl alcohol was removed and the remaining mixture was extracted with ethyl acetate (3×5 ml). The combined organic layers were dried over sodium sulfate and concentrated to give 1-methyl-6-methoxycarbonylbenzotriazole-4-carbaldehyde oxime (0.14 g). 1H-NMR (400 MHz, DMSO): 12.06 (s, 1H), 8.55 (s, 1H), 8.11 (d, 1H), 7.79 (d, 1H), 4.57 (s, 3H), 3.93 (s, 3H). LC-MS: m/z=235.08 (M+H).

Provenance & Evidence