(7-Bromo-2-methyl-benzo[d]oxazol-4-yl)methanol → 7-Bromo-2-methyl-benzo[d]oxazole-4-carbaldehyde

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Reaction Steps

To a solution of (7-bromo-2-methyl-benzo[d]oxazol-4-yl) methanol (5.16 g) in dichloromethane (300 ml) was added manganese(IV) oxide (59.9 g) and the suspension stirred at ambient temperature for 16 hours. The reaction mixture was filtered through a plug of silica gel and the filtrate concentrated to give 7-bromo-2-methyl-benzo[d]oxazole-4-carbaldehyde (3.23 g). LC-MS: RT=1.83 min, [M+H]+=240.0/242.0, using the following method:

Provenance & Evidence